Gee, boosting prevents N protein production, and now…evidence of T cell exhaustion?

Oct 30, 2022

Hmmm if T cell exhaustion occurs in constant neoplasm production from cancer, then our discussion of constant vaccination causing T-cell exhaustion isn’t quite misinformation, now, is it? 🤔

Daniel, Yost, Hsiung, et al. generate a single-cell multiomic atlas of T cell exhaustion in chronic viral infection, which reveals molecular programs of exhausted T cell subsets, identifies divergent clonal exhausted T cell differentiation trajectories and nominates TCR signal strength as a driver of clonal fate.

www.nature.comDivergent clonal differentiation trajectories of T cell exhaustion - Nature ImmunologyDaniel, Yost, Hsiung, et al. generate a single-cell multiomic atlas of T cell exhaustion in chronic viral infection, which reveals molecular programs of exhausted T cell subsets, identifies divergent clonal exhausted T cell differentiation trajectories and nominates TCR signal strength as a driver of clonal fate.

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