In Stanley Kubrick's adaptation of a novella by Arthur Schnitzler, Eyes Wide Shut, Cruise is the main protagonist alongside his then-wife, Nicole Kidman. 

The actor plays the role of Dr. William Harford, who is married to Alice Harford 

. 

In this strange psychosexual narrative that flirts with the nature of dreams, desire, and male expectations, the couple struggles to deal with possible infidelity and, most importantly, trusting one another.